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Before Buying an ATX Motherboard, You Should Know These Facts
One of the most important differences between Mini ITX and the two ATX motherboard types is the number of RAM slots that the motherboard comes with.
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To save yourself a lot of hassle with custom brackets, case modification and PCIe riser cables, you want a motherboard with either 7+ PCIe 3.0 full length slots or at least 4 slots with dual/triple spacing between them.
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For maximum PCIe 5.0 support with AMD CPUs, use a motherboard with the X670E or B650E chipset. The X670 chipset only supports PCIe 4.0 for x8 and x16 slots.